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Publication Date: 12/2017
Pages: 5
PDF Format
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The influence of lactose fines in dry powder inhaler formulations

A study of the extent to which micronized lactose fines may improve dispersion behavior of DPI formulations

This study investigated the influence of lactose fines in ternary powder mixtures for inhalation by using different inhalers. Mixtures with and without commercially available lactose fines and the hydrophobic model drug budesonide were prepared. Aerodynamic behavior was tested with a Next Generation Impactor and three devices (Novolizer®, Cyclohaler® and Rack), chosen because of their different dispersion mechanisms. The addition of extrinsic lactose fines showed a significant improvement in the dispersion behavior for all tested devices.

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