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Publication Date: 08/2013
Pages: 6
PDF Format
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Unveiling dislocations in API crystallinity after mechanical stress due to milling

For robust formulations, it is critical to understand milling-induced transformations and behavior upon performance and stability of materials subjected to milling.

The majority of active pharmaceutical ingredients (APIs) are crystalline materials, whose crystal lattice structure determines, to a large extent, the fracture patterns leading to particle size reduction upon milling. In this investigation, the integrity of the crystal after mechanical stress was studied on a model compound to show the evolution of properties of crystalline solids when subjected to milling.

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