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Inhalation is the only technical publication devoted exclusively to readers involved in development and production of pulmonary or nasal delivered pharmaceuticals.
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Publication Date: 02/2008
Pages: 3
PDF Format
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Inverse gas chromatography

A novel finite dilution IGC technique for the physicochemical characterization and optimization of dry powder inhalation formulations.

In the October 2007 issue of Inhalation, Andrew Otte and M. Teresa Carvajal presented a comprehensive overview of solid surface energy principles and applied measurement techniques for DPI formulations, including infinite dilution inverse gas chromatography (IGC). This follow-up article focuses specifically on the use of IGC for the determination of surface energy as a function of processing conditions for both API and excipient carrier molecules used in inhalable formulations and introduces a novel finite dilution approach that offers a unique new method of profiling surface heterogeneity, which plays a major role in drug-carrier interactions. This extremely sensitive approach provides data of unparalleled specificity that can benefit every stage of the DPI formulation process.

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