Development of Idealized Throat Replicas for Inhaler Testing, 7/11
CD of live broadcast 7/14/11
For most inhalers, avoiding mouth-throat deposition is an important aspect of device performance when delivering drugs to the lungs. However, regulatory throats used in benchtop testing, such as the USP throat, are known to underestimate mouth-throat deposition quite significantly for some aerosols. This makes it more difficult to extrapolate in vivo performance based on in vitro tests with such throats. Various researchers have instead found that realistic throats, typically built using rapid prototyping of CT or MRI scans of a particular subject, may allow more representative in vitro estimation of mouth-throat deposition. However, such subject-specific realistic throats are unlikely to undergo widespread adoption as standard throats for general use.
Experimental measurements from the author’s laboratory that highlight the essential fluid and aerosol mechanics of the mouth-throat will be presented. Idealized geometries that capture these mechanics will also be discussed. These idealized geometries may be useful to those wanting to obtain more realistic benchtop estimates of mouth-throat deposition during inhaler development.
Presenter: Warren Finlay, Ph.D., a Professor at the University of Alberta, Edmonton, Alberta, Canada, is the Founder and Director of the Aerosol Research Laboratory of Alberta and a McCalla Professor. Dr. Finlay holds 19 patents and patent applications and has published extensively. Author of the book, “The Mechanics of Inhaled Pharmaceutical Aerosols: An Introduction,” he has also published more than 100 refereed journal papers, nearly 200 refereed conference articles and seven book chapters.
Moderator: Vicki Schuman, editor of Inhalation
CDs are non-returnable/non-refundable