• Publication Date: 04/01/2012
  • Author(s):
    Copley, Mark Kippax, Paul
  • Organization(s):
    Copley Scientific Malvern Instruments
  • Article Type: Technical Articles
  • Subjects: Instruments, Nasal Delivery, Particle Characterization, Product Development/Formulation
An examination of two complementary techniques: Laser diffraction and cascade impaction

In its draft guidance “Bioavailability and Bioequivalence Studies for Nasal Aerosols and Nasal Sprays for Local Action” (April 2003),4 the FDA highlights the use of laser diffraction for measurement of the particle size distribution of both nasal sprays and nasal aerosols. Cascade impaction is recommended for scrutiny of the finer end of the distribution. This article examines these two complementary techniques, explains in some detail how they work and shows how they can be applied in tandem to deliver valuable information for nasal product characterization.

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