• Publication Date: 06/01/2024
  • Author(s):
    Doktorovová, Slavomíra Henriques, Patrícia
  • Organization(s):
    Hovione FarmaCiencia University of Coimbra
  • Article Type: Technical Articles
  • Subjects: Nasal Delivery, Particle Characterization, Product Development/Formulation

Nasal powders have been recognized as an opportunity to improve stability and residence time on the nasal mucosa compared with liquids, where amorphous powders favor the formulation of poorly soluble drugs with improved biopharmaceutical profile, namely faster onset of action. This article presents two case studies focused on particle engineering strategies and nasal powder formulation of a model poorly soluble drug for systemic delivery, while evaluating performance methodologies.

The study results confirmed the suitability of spray drying to manufacture particles for nasal delivery. The supersaturated solutions resulted in enhanced in vitro release performance. The pharmacokinetic studies in Wistar rats confirmed the potential of amorphous solid dispersions to provide faster onset of action for poorly soluble drugs and indicated supersaturation affects and promotes absorption. In vitro nasal deposition and drug release methodologies proved helpful in selecting lead formulations. These studies can foster better comprehension of formulation, process and performance evaluation of nasal powders.

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