Automated SEM-EDS can be used for foreign particulate matter testing, API-specific particle sizing and API morphology testing. Case studies with an MDI, a DPI and a nebulizer are presented.
Automated SEM-EDS can provide high-magnification images and elemental information, as well as detailed morphological and shape information in a quantitative method for easier comparison of two products. Depending on the drug type and preparation method, it can detect particles in the submicron range. It also enables efficient collection of large data sets in a matter of hours, limiting the burden of scientist time and eliminating the subjectivity of manual analysis.