• Publication Date: 04/01/2024
  • Author(s):
    Forbes, Ben Kilgour, Jo Moore, Simon
  • Organization(s):
    Apconix King’s College London Labcorp Early Development Laboratories Limited Mereside Toxicology Consulting Regulatory Science Associates
  • Article Type: Back Page
  • Subjects: Education/Professional Development, Product Development/Formulation, Testing, Validation, and Regulatory Compliance

The Association of Inhalation Toxicologists (AIT) presented a workshop at the 2023 Drug Delivery to the Lungs Conference. The focus was on methods used for in vitro toxicity screening, in vivo study designs, toxicological endpoints and regulatory toxicology. The workshop also covered technical aspects of the generation, characterization and dosimetry of aerosols in toxicology studies.

Carsten Ehrhardt reviewed the advantages and disadvantages of inhaled medicines and their development. Victoria Hutter provided an overview of in vitro toxicology and available cell models. An(Tony) Grasiewicz addressed delivery of test materials in different respirable forms, focusing on liquid droplet and powder aerosols. Paul Smith explained the regulatory toxicology requirements that apply to inhaled medicines. Jo Kilgour addressed novel excipients for inhalation and preclinical nasal toxicology studies. The workshop chairs, Ben Forbes and Viktoria McDonald, facilitated a panel debate to complete the workshop.

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