• Publication Date: 02/01/2008
  • Author(s):
    Copley, Mark
  • Organization(s):
    Copley Scientific
  • Article Type: Technical Articles
  • Subjects: Instruments, Particle Characterization
Theory, design, and practical information for optimal testing.

Cascade impaction is the only particle size measurement technique that can differentiate API from other components in a formulation, so this technique is the key analytical method for both development and quality assurance of inhaled products; all of the major pharmaceutical regulatory agencies specify the use of cascade impactors for these analyses. Accurate testing is critical, and impactor testing requires substantial investments of time and money. A basic understanding of the design and operation of cascade impactors and their operating parameters can help achieve optimum performance in return.

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