- Author(s):
- Organization(s):
Copley Scientific Intertek-Melbourn Jolyon Mitchell Inhaler Consulting Services, Inc.
This study demonstrates that the Child “Alberta” Idealized Throat provides data more representative of in vivo throat deposition than the standard USP/Ph. Eur. induction port. The results from this investigation are broadly similar to the outcomes from a previous evaluation of the Adult “Alberta” Idealized Throat by the authors.
It has proven difficult to develop robust in vitro/in vivo correlations (IVIVCs) when assessing the performance of OIPs in the clinical setting. The results of this investigation of the Child “Alberta” Idealized Throat are broadly similar to the outcomes from a previous evaluation of the Adult “Alberta” Idealized Throat with a pMDI-delivered aerosol, confirming the trend that the Ph.Eur./USP inlet removes fewer of the larger particles from the incoming aerosol than is likely to be the case in reality.