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Contributions of mechanical stress on the “frustrated” thermal response of griseofulvin

  • Publication Date: 08/01/2012
  • Author(s):
    Carvajal, M. Teresa Ito, Takanori
  • Organization(s):
    Purdue University
  • Article Type: Technical Articles
  • Subjects: Particle Characterization, Particle Manufacturing, Product Development/Formulation
During milling, changes in material properties are mainly induced by the degree and extent of exposure to mechanical stress, which affects thermal response and stability of materials

The milling process and exposure time may give unfavorable effects to the physico-chemical properties of the active pharmaceutical ingredient (API). In particular, amorphization by milling has been a problem for drug development.10-13 The generation of amorphous regions changes the physico-chemical properties and stability of APIs. Therefore, it is important to find suitable milling operation conditions for each compound.

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