Dry powder inhalers—More than 170 years of development; Where to next? and Dry powder inhalers: A new look at what may be next

The earliest reference to therapeutic dry powder inhalation may also be the earliest reference to “engineered particles,” dating from 1849, in London. An initial article looks at the history of dry powder inhalers, including devices and formulations, and discusses considerations for future DPIs. Then an interview takes a new look at current challenges and opportunities for DPIs.

In an initial article, the authors provide a brief history of dry powder inhalers then discuss considerations for future development such as formulation, dose storage, moisture protection and metering, de-aggregative processes, counters, the environment, patient considerations and non-respiratory indications. In a new interview, author Mark Sanders discusses his perspectives on current challenges and opportunities for DPIs, including ways dry powder inhalers (DPIs) might improve patient technique, patient adherence, smart inhalers and delivery of biologics.