• Publication Date: 02/01/2026
  • Author(s):
    Ali, Syed Yusuf Arpornsuksant, Punthitra Bai, Yunong Coles, George L. Egyen-Davis, Damali Jassal, Mandeep Kedia, Varun Lee, Carlton K. K. Pitaktong, Isaree Xu, Maxwell A. Zhu, Lily
  • Organization(s):
    Johns Hopkins University
  • Article Type: Technical Articles
  • Subjects: Device Design, Devices and Components, Filling/Packaging, Product Development/Formulation, Respiratory Medicine

A significant challenge for pediatric asthma patients lies in generating the proper inspiratory flow required for effective drug delivery from dry powder inhalers. Furthermore, there are currently no devices available to assist these patients. In response, we propose a novel adaptor named the FlowMate®, which features a delay-and-release mechanism. It aims to ensure consistent and adequate drug delivery to the lungs for pediatric patients and those with limited inspiratory capacity.

Preliminary testing supports its feasibility and potential to enhance medication deposition. Further studies are needed to validate its clinical efficacy, refine design features and optimize performance under real-world conditions. Future work includes particle size testing using cascade impactor studies to assess the impact of the adaptor on medication particle size and distribution. Should results be positive, this device design could be incorporated into the refinement of the next generation of DPI delivery devices.

February 2026, Volume 20(1), pages 29-34

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