Clinically relevant in vitro tests that assess regional deposition for nasal delivery devices may be advantageous in the production of new nasal drug delivery products and to accelerate the development of generic products. The article reviews various nasal airway models. In addition, it presents results of a VCU study to identify critical patient-use variables that should be controlled during testing. A VCU study also demonstrated the range of nasal deposition that can be achieved in a single airway model with just manipulation of two factor experimental conditions and their interactions.
Evaluating simulated patient use in realistic nasal airway models for the in vitro characterization of nasal spray products
A review of efforts to characterize nasal sprays and highlights of some VCU’s studies developing realistic in vitro testing methods