• Publication Date: 06/01/2015
  • Author(s):
    Nerbrink, Ola Ulvenlund, Stefan
  • Organization(s):
    CR Competence AB Medicon Valley Inhalation Consortium Respiron Consulting AB
  • Article Type: Technical Articles
  • Subjects: Device Design, Industry Issues and Trends, Product Development/Formulation
This article examines the critical role of formulation science in the development of tomorrow’s miniaturized devices for liquid inhalation.

To achieve a true step-change in nebulization, next-generation nebulizers need to be designed in such a way that they (1) are inconspicuous during patient use, (2) allow for the patient to conveniently carry the device in everyday life, (3) administer the dose in a shorter time, and (4) preferably do so with only one or two inhalations. When these requirements are fulfilled, the user-friendliness of nebulizers is comparable to that of dry powder inhalers (DPIs) and pressurized metered dose inhalers (pMDIs). However, these requirements also translate as a dramatic and technically challenging miniaturization of the device, compared to conventional technology.

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