• Publication Date: 04/01/2020
  • Author(s):
    Duke, Daniel J.
  • Organization(s):
    Monash University
  • Article Type: Technical Articles
  • Subjects: Device Design, Instruments, Particle Characterization, Product Development/Formulation
Unlike many traditional measurement techniques, synchrotron measurements can provide direct evidence of the effects of changes to actuator design and formulation composition on the behavior of a device, a formulation or both, rather than simply indicating a change in the end result. This can shorten the design feedback loop and allow for more rapid development and assessment of prototype devices.

Synchrotron X-rays can provide valuable quantitative information on drug distribution, spray density, droplet and particle properties; metrics that are difficult or virtually impossible to obtain by other means. Unlike many traditional measurement techniques, synchrotron measurements can provide direct evidence of the effects of changes to actuator design and formulation composition on the behavior of a device, a formulation or both, rather than simply indicating a change in the end result (such as determination of fine particle fraction). This can shorten the design feedback loop and allow for more rapid development and assessment of prototype devices. The fundamental insights gained through these measurements can facilitate the development of models to support the design of new inhaled pharmaceutical products.

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