• Publication Date: 02/01/2009
  • Author(s):
    Noakes, Tim
  • Organization(s):
    Ineos Fluor
  • Article Type: Technical Articles
  • Subjects: Excipients
How manufacturers insure that hydrofluoroalkanes used in metered dose inhalers meet purity and performance specifications.

Among all of the various types of excipients, HFAs are subject to some of the tightest controls and specifications. As HFAs have now replaced chlorofluorocarbons (CFCs) in most parts of the world, it is useful to take a look at how manufacturers produce these gases, the controls used to assure high levels of product quality, and the contrast between the stringent requirements for their manufacture with the simpler standards that were applied to CFCs.

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