Recently, researchers have been exploring the use of a novel, semi-permeable system component made of a reticulated foam for use with suspension formulations to alleviate valve sampling problems. Reticulated foams feature open pore structures with specified numbers of pores per inch. Using the foam as a holding chamber adjacent to the valve sampling point prevents flocs forming in a suspension formulation from growing any larger than the volume of the pores.
Improving dose reproducibility from MDIs
Using a particulate semi-permeable matrix (PSPM) foam component as a holding chamber for a valve improves sampling consistency in flocculating suspensions.