• Publication Date: 06/01/2024
  • Author(s):
    Chin, William Wei Lim Sandoval, Michael A. Watts, Alan B.
  • Organization(s):
    Catalent Pharma Solutions University of Texas at Austin, College of Pharmacy
  • Article Type: Technical Articles
  • Subjects: Nasal Delivery, Particle Characterization, Product Development/Formulation

Nasal powder formulations represent a significant stride in drug delivery innovation, offering the potential for simplified, preservative-free compositions. Increased chemical stability and enhanced capacity for higher drug loads are additional benefits offered by formulating as a dry powder. Application of established production technologies, such as spray drying, allows for the design and manufacture of readily dispersible, shelf-stable powders in a scalable process.

This article discusses a wide range of topics on these innovative formulations including potential indications and applications such as neurological disorders, vaccines, interactions with mucosal barriers and emergency anaphylaxis treatment; formulation and characterization approaches, particularly formulation considerations and excipient selection; manufacture of nasal powder utilizing spray drying and new technologies such as thin-film freezer drying; in vitro characterization; and trends and challenges entering and within the market, commercial examples and global regulatory trends.

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