INFORM2020 is a five-year collaboration of academia and industry to investigate critical parameters that influence the performance of dry powder inhaled (DPI) formulations. In part, the collaboration has been attempting to shed light on key questions through X-ray microscopy, which can offer new insights into the microstructure of inhalable formulations for DPIs. The article also includes a brief interview with the authors.
New perspectives on the microstructure of inhalable formulations through laboratory 3-D X-ray microscopy
Unanswered questions relating to pre-aerosolized formulations include (1) What does the blend formulation truly look like? (2) How do different parts of the blend interact with each other? (3) How do we quantify the microstructure? (4) How does the microstructure change due to manufacturing processes or storage? This article explores how X-ray microscopy can offer new insights into the microstructure of inhalable formulations for dry powder inhalers. The findings are part of the INFORM2020 collaboration.