• Publication Date: 10/01/2013
  • Author(s):
    Hamilton, Melanie Prime, David
  • Organization(s):
  • Article Type: Technical Articles
  • Subjects: Instruments, Product Development/Formulation, Testing, Validation, and Regulatory Compliance
Simulating human inhalation at fixed levels of inspiratory effort, it allows flow rates through DPIs to vary with device resistivity and enables rapid, fair DPI testing and comparison.

The GSK Hydraulic Lung was developed to simulate human inhalation to allow comparative in vitro testing of dry powder inhalers (DPIs) at a consistent level of inspiratory effort, rather than a single flow rate or pressure drop. It has also been used to explore the relationship between inspiratory effort, device resistance and flow rate or pressure drop, to provide a means of calculating relative flow rates appropriate for testing different DPIs.

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