• Publication Date: 02/01/2024
  • Author(s):
    Ordoubadi, Mani
  • Organization(s):
    University of Alberta
  • Article Type: Technical Articles
  • Subjects: Excipients, Particle Manufacturing, Product Development/Formulation

There has been a surge in interest surrounding the development of carrier-free dry powder formulations intended for pulmonary drug delivery. Spray drying is the preferred technique for the production of carrier-free dry powder formulations.

Shell-forming excipients can play a pivotal role in overcoming challenges related to spray drying including particle cohesion, hygroscopicity and overall stability. Due to their unique physico-chemical properties, this class of excipients can form a protective layer on the surface of the droplet during drying, resulting in core-shell structured particles. By strategically incorporating shell formers into spray-dried products, formulators can enhance dispersibility and mitigate the potential drawbacks associated with cohesive powders. This article delves into the multifaceted role of shell formers, shedding light on their mechanisms of action, impact on particle properties and a practical methodology for their formulation design.

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