• Publication Date: 10/01/2018
  • Author(s):
    Birk, Gudrun Rhein, Nancy Scherließ, Regina
  • Organization(s):
    Kiel University Merck KGaA
  • Article Type: Technical Articles
  • Subjects: Devices and Components, Excipients, Product Development/Formulation
A study of the influence of blend preparation and storage stability of a mannitol carrier material in DPI formulations

It is known from lactose-based blends, that the choice of blender type and blending conditions can strongly influence aerodynamic properties, whereas this has not yet been examined with mannitol-based blends. In addition, lactose-based blends are sensitive to humidity and their physical properties, as well as their aerodynamic behavior, may change depending on storage conditions. Therefore, the stability of mannitol-based blends stored under three different conditions for 14 months with mannitol as a carrier and two model APIs—namely budesonide (BUD) as a hydrophobic example and salbutamol sulphate (SBS) as a hydrophilic example—was examined with respect to aerodynamic performance during storage.

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