• Publication Date: 06/01/2019
  • Author(s):
    Bhat, Jnanadeva Diez, Fernando Giripunje, Ajay Kalafat, Justin Patil, Deepak Powale, Sanjay
  • Organization(s):
    ACG Capsules
  • Article Type: Technical Articles
  • Subjects: Capsules and Blisters, Devices and Components, Product Development/Formulation
Data on capsule puncturing forces and consistency in capsule puncturing could provide benefits for capsule manufacturers, developers of capsule-based inhalers and patients.

This article discusses principles of capsule puncturing then presents a comparative study of puncturing forces in gelatin and HPMC capsules. There are multiple applications in which the testing presented here could be beneficial, to capsule manufacturers for their quality control measures, to manufacturers of capsule-based inhalation products and, by extension, to patients utilizing those medications. These options all involve the concept of consistent force necessary for puncturing capsules in an inhalation device.

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