- Author(s):
- Organization(s):
Purdue University Universidad Autónoma del Estado de Morelos
For robust formulations, it is critical to understand milling-induced transformations and behavior upon performance and stability of materials subjected to milling.
The majority of active pharmaceutical ingredients (APIs) are crystalline materials, whose crystal lattice structure determines, to a large extent, the fracture patterns leading to particle size reduction upon milling. In this investigation, the integrity of the crystal after mechanical stress was studied on a model compound to show the evolution of properties of crystalline solids when subjected to milling.