• Publication Date: 08/01/2013
  • Author(s):
    Carvajal, M. Teresa Guzmán-Villanueva, Diana Herrera-Ruiz, Dea
  • Organization(s):
    Purdue University Universidad Autónoma del Estado de Morelos
  • Article Type: Technical Articles
  • Subjects: Particle Characterization, Particle Manufacturing, Product Development/Formulation
For robust formulations, it is critical to understand milling-induced transformations and behavior upon performance and stability of materials subjected to milling.

The majority of active pharmaceutical ingredients (APIs) are crystalline materials, whose crystal lattice structure determines, to a large extent, the fracture patterns leading to particle size reduction upon milling. In this investigation, the integrity of the crystal after mechanical stress was studied on a model compound to show the evolution of properties of crystalline solids when subjected to milling.

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