Recently, researchers have been exploring the use of a novel, semi-permeable system component made of a reticulated foam for use with suspension formulations to alleviate valve sampling problems. Reticulated foams feature open pore structures with specified numbers of pores per inch. Using the foam as a holding chamber adjacent to the valve sampling point prevents […]
With the growing number of dry powder inhalers, it has been well recognized that a unique set of requirements related to these formulations exist separately from traditional, solid-dose, oral formulations. These requirements have implications for devices, containers and manufacturing equipment, such that a successful product will ultimately be the partnership of these. This article will […]
This article will describe some established and emerging imaging systems that can be utilized to picture two-piece capsules and will highlight potential benefits and limitations of each.
With so much recent interest in the use of computational fluid dynamics (CFD) for developing inhalation and nasal products – an entire afternoon at RDD 2008 was devoted to papers on the topic – you may be wondering how to get started using CFD yourself. The benefits are pretty obvious; why spend months tweaking device […]
A lasting solution would be the adoption of sample-independent quality standards and statistical process controls, for example, by incorporating in the pharmaceutical industry some of the statistical methods standardized by ASTM, ISO and other standard-setting organizations, appropriately adjusted throughout a product’s lifecycle (from early to late development to commercial production).
Recently, specially-designed devices have emerged that can target the delivery of sprays or powders to the olfactory region of the nose, thereby enabling delivery of the drug directly to the central nervous system. This article examines nasal spray formulation parameters and excipients and their influence on key in vitro tests.
The study demonstrates the importance of lactose selection studies during formulation development and the need to perform such studies for every new development project. Although one carrier material may work ideally for an existing formulation, it may be wise to use a different carrier when changing the API, the concentration of the API or the […]
Although nasal aerosol products to treat pain have been available for a number of years, recent developments have brought renewed interest to this market. In addition, estimated at over two billion dollars in 2009, the world market for nasally administered systemic drugs has seen strong growth in the last few years. This article will look […]
The past few years have seen the leveling off of new molecular entities (NMEs) reaching the market,1-3 partly as a result of increasing drug development costs and higher regulatory standards for drug approval. Yet many opportunities still exist in this changing pharmaceutical market for both innovator and generic pharmaceutical companies who are willing to seek […]
ECs share a common purpose with conventional pharmaceutical inhalation devices: they produce aerosols intended to be orally inhaled into the respiratory tract. They seemingly serve the same goal of pulmonary delivery so it is worthwhile to examine ECs from the viewpoint of inhalation drug development and explore what can be learned from them.