• December 12, 2017

As the FDA’s deadline for conversion from chlorofluorocarbons (CFCs) to hydrofluoroalkane (HFA) in MDIs approaches, we ask 3M’s Barbara Davidson, Georgina Fradley, and Simon Cawthorne how the transition is going.

  • November 29, 2017

Among all of the various types of excipients, HFAs are subject to some of the tightest controls and specifications. As HFAs have now replaced chlorofluorocarbons (CFCs) in most parts of the world, it is useful to take a look at how manufacturers produce these gases, the controls used to assure high levels of product quality, […]

Recently, specially-designed devices have emerged that can target the delivery of sprays or powders to the olfactory region of the nose, thereby enabling delivery of the drug directly to the central nervous system. This article examines nasal spray formulation parameters and excipients and their influence on key in vitro tests.

Because most conventional dry powder inhaler (DPI) products contain an extremely small dose of active pharmaceutical ingredient (API) in the form of a very fine, highly cohesive powder, the majority of DPIs rely on excipients, especially lactose, to overcome formulation performance problems. Although a few DPIs, such as AstraZeneca’s Turbohaler Pulmicort budesonide product, include no […]

The study demonstrates the importance of lactose selection studies during formulation development and the need to perform such studies for every new development project. Although one carrier material may work ideally for an existing formulation, it may be wise to use a different carrier when changing the API, the concentration of the API or the […]

  • November 21, 2017

There are several commercial pharmaceuticals with CyD-based formulations for parenteral use: but as far as it is known there aren’t yet any approved for inhalation delivery to treat diseases of the lung. To improve treatment of lung disease, CyDs can be used to solubilize poorly-soluble molecules for delivery in solution inhalers. Alternatively, these solutions can […]

  • November 20, 2017

The ability to measure particle/particle interactions in pressurized metered dose inhaler (pMDI) propellants is central to excipient screening of suspension based pMDI formulations. Colloidal Probe Microscopy (CPM) is a variation of Atomic Force Microscopy (AFM) used to measure the interaction forces between a colloidal particle attached to an AFM tip and another particle/substrate. CPM is […]