In this opinion article, the authors discuss potential benefits of utilizing both empirical methods and in silico models for inhaled drug development. They also present two case studies, on modeling and the transition to low-GWP propellants, and modeling and predicting particle deposition. From fluid dynamics and propellant evaporation to PK and regional lung deposition simulations, […]
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There are many disadvantages associated with in vivo animal models and excised nasal mucosa, including ethical considerations and interspecies variability. In vitro nasal anatomical models that are more physiologically representative of the nasal cavity can be of fundamental importance to study nasal drug deposition and predict in vitro–in vivo correlation (IVIVC), a regulatory requirement for […]
The first Lung Modeling Congress was held in November 2023 to address the challenges related to lung modeling and creation of digital twins of the human respiratory system. This article, together with a previous article in Inhalation, presents a summary of the current state-of-the-art and future challenges in various research areas and was written by […]
To address the challenges related to lung modeling and creation of digital twins of the human respiratory system, the first Lung Modeling Congress was held in November 2023. This article, together with a second article in an upcoming issue of Inhalation, presents a summary of the current state-of-the-art and future challenges in various research areas […]