While multiple particle engineering approaches are available, spray drying and jet milling are proven, scalable approaches and drug developers may benefit from considering them as a first pass. By evaluating these approaches initially, developers can determine whether a more complicated approach is required and which path is best suited for the active pharmaceutical ingredient and […]
Over the past decades, important progress has been achieved through the introduction of new capsule types and advanced particle engineering. A range of HPMC capsules with distinct properties as well as customizable specifcations have broadened the design space for cDPI systems. The use of spray-drying technology for advanced particle engineering allows the delivery of much […]
Through adaptations of advanced technologies from the microelectronics industry, Liquidia Technologies has recently applied a mold-based particle engineering platform, termed PRINT, which stands for Particle Replication In Non-wetting Templates,14 to the generation of inhalation powders.15 Unlike other particle engineering technologies, this platform achieves uniform particle shape, size, and morphology defined by the input mold feature.
Developing DPIs for new indications with challenging doses, such as antibiotics, require the products to possess high aerosolization efficiency and superior performance consistency. To achieve this, particle engineering appears necessary. Dry coating equipment appears to be highly effective, simple, scalable and economical. It can also complement current industrial manufacturing processes. Therefore, this approach appears to […]
Design of drug particles for inhalation medicines is an important factor in providing high quality, efficacious and safe medicines. Various approaches for generating micron sized drug particles required are summarized here and the key benefits of a controllable, single step, efficient process highlighted. The antisolvent supercritical fluid method is now well understood, proven at scale […]
The studies presented show formulation approaches that can meet the challenges of nasal dry powder vaccines.
This is the second in a series of articles by Purdue scientists on new technologies in inhalation drug development. As environmental concerns have lead pharmaceutical companies and regulators to work towards eliminating the use of propellants in inhalation devices, much of the recent research for pulmonary drug delivery has turned towards the use of dry […]
An abundance of academic and industrial research into alternative particle production techniques has taken place over the years, but as yet only one product (spray-dried insulin) has reached the market. Many product developers perceive this lack of progress as a failure of alternative techniques to deliver on the large scale, but progress has also suffered […]
One of the key factors affecting delivery of drugs to the lungs is particle size. This is relevant for both dry powder inhaler (DPI) and suspension pressurized metered dose inhaler (pMDI) formulations. Depending upon the specific airway target site, the particle size can vary slightly but generally, an aerodynamic particle size distribution (PSD) of 1-6 […]