• February 14, 2024

There has been a surge in interest surrounding the development of carrier-free dry powder formulations intended for pulmonary drug delivery. Spray drying is the preferred technique for the production of carrier-free dry powder formulations. Shell-forming excipients can play a pivotal role in overcoming challenges related to spray drying including particle cohesion, hygroscopicity and overall stability. […]

  • December 1, 2023

This article discusses development of polymeric nanoparticles intended to obtain optimal features for loading therapeutic antibodies and be formulated into dry powders for inhalable lung cancer treatment. This may reduce serious side effects and toxicity and support therapeutic adherence, effectiveness and safety. The article also discusses dry powder formulation with respect to particle deposition profile […]

  • April 7, 2023

Spray drying is used to produce engineered, inhalable dry powders and is a critical tool for new drug developers. It enables production of powders with a tightly controlled range of particle sizes and solid-state properties. Formulators have control over the crystalline and amorphous character and radial distribution of components and particle morphology. This comes from […]

  • February 11, 2023

Excipient enhanced growth (EEG) is progressing through toxicological studies and showing promise for treatment of asthma and lung cancer by delivering active molecules to target sites in the lungs. This article discusses development of two candidates, budesonide and gemcitabine, for local lung delivery using this formulation approach in combination with traditional spray drying for the […]

  • December 5, 2022

In spray-dried formulations, various excipients or carriers are incorporated to improve the aerosolization behavior, stability and mechanical properties of active pharmaceutical ingredients (APIs) as well as to modify the pharmacokinetics and pharmacodynamics of APIs. Sugars are the most common excipients used as diluents and flow enhancers. In addition, sugars can provide hydrogen bonding and act […]

  • August 4, 2020

While multiple particle engineering approaches are available, spray drying and jet milling are proven, scalable approaches and drug developers may benefit from considering them as a first pass. By evaluating these approaches initially, developers can determine whether a more complicated approach is required and which path is best suited for the active pharmaceutical ingredient and […]

  • July 23, 2018

Over the past decades, important progress has been achieved through the introduction of new capsule types and advanced particle engineering. A range of HPMC capsules with distinct properties as well as customizable specifcations have broadened the design space for cDPI systems. The use of spray-drying technology for advanced particle engineering allows the delivery of much […]

  • December 14, 2017

Through adaptations of advanced technologies from the microelectronics industry, Liquidia Technologies has recently applied a mold-based particle engineering platform, termed PRINT, which stands for Particle Replication In Non-wetting Templates,14 to the generation of inhalation powders.15 Unlike other particle engineering technologies, this platform achieves uniform particle shape, size, and morphology defined by the input mold feature.

Developing DPIs for new indications with challenging doses, such as antibiotics, require the products to possess high aerosolization efficiency and superior performance consistency. To achieve this, particle engineering appears necessary. Dry coating equipment appears to be highly effective, simple, scalable and economical. It can also complement current industrial manufacturing processes. Therefore, this approach appears to […]