Carrier-based interactive powder mixtures are a cornerstone of drug delivery by inhalation, yet optimization is hampered by the complex interplay of various carrier particle properties including their geometry. Conventional approaches for carrier particle manufacture such as milling, sieving or spray drying can modify multiple attributes simultaneously, making it challenging to assess the effect of particle […]
Archives
This in vitro study evaluated how rational selection of device resistance can be used to minimize flow rate dependence in dose delivery in vivo. Aerosol performance of amphotericin B inhalation powder was assessed using a Next Generation Impactor (NGI) at a range of pressure drops (1, 2, 4 and 6 kPa) with low, medium, high, […]
Pulmonary delivery of therapeutic proteins for the management of respiratory diseases has been receiving research attention, particularly after the COVID-19 pandemic. Yet its development barriers include the propensity of proteins to form aggregates, which poses a major challenge to protein stability. This article presents a summary on protein aggregation, illustrating its significance and the challenges […]
There has been a surge in interest surrounding the development of carrier-free dry powder formulations intended for pulmonary drug delivery. Spray drying is the preferred technique for the production of carrier-free dry powder formulations. Shell-forming excipients can play a pivotal role in overcoming challenges related to spray drying including particle cohesion, hygroscopicity and overall stability. […]
This article discusses development of polymeric nanoparticles intended to obtain optimal features for loading therapeutic antibodies and be formulated into dry powders for inhalable lung cancer treatment. This may reduce serious side effects and toxicity and support therapeutic adherence, effectiveness and safety. The article also discusses dry powder formulation with respect to particle deposition profile […]
Spray drying is used to produce engineered, inhalable dry powders and is a critical tool for new drug developers. It enables production of powders with a tightly controlled range of particle sizes and solid-state properties. Formulators have control over the crystalline and amorphous character and radial distribution of components and particle morphology. This comes from […]
Excipient enhanced growth (EEG) is progressing through toxicological studies and showing promise for treatment of asthma and lung cancer by delivering active molecules to target sites in the lungs. This article discusses development of two candidates, budesonide and gemcitabine, for local lung delivery using this formulation approach in combination with traditional spray drying for the […]
In spray-dried formulations, various excipients or carriers are incorporated to improve the aerosolization behavior, stability and mechanical properties of active pharmaceutical ingredients (APIs) as well as to modify the pharmacokinetics and pharmacodynamics of APIs. Sugars are the most common excipients used as diluents and flow enhancers. In addition, sugars can provide hydrogen bonding and act […]
While multiple particle engineering approaches are available, spray drying and jet milling are proven, scalable approaches and drug developers may benefit from considering them as a first pass. By evaluating these approaches initially, developers can determine whether a more complicated approach is required and which path is best suited for the active pharmaceutical ingredient and […]
Over the past decades, important progress has been achieved through the introduction of new capsule types and advanced particle engineering. A range of HPMC capsules with distinct properties as well as customizable specifcations have broadened the design space for cDPI systems. The use of spray-drying technology for advanced particle engineering allows the delivery of much […]