An inflammatory molecule called LIGHT appears to be the cause of tissue remodeling and life-threatening airway damage in patients with severe asthma, according to scientists from the La Jolla Institute for Immunology (LJI). Findings suggest that LIGHT plays a dominant role and coordinates the tissue remodeling process. Moreover, the study is “the first to show […]
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A grant from the United States Environmental Protection Agency (EPA) is supporting Breath SMART (Safety Monitoring Air ‘Round Town). The program will create a community-based network of air quality monitors in Milwaukee, Wisconsin neighborhoods with the highest rates of hospitalizations and emergency room visits related to asthma. Monitors will be installed at approximately 15 schools […]
A new United States law recognizing sesame as the ninth major food allergen is having unintended consequences. Some food manufacturers and commercial bakeries that support restaurants, stock grocery shelves and supply schools are intentionally adding sesame to various products that previously did not contain it. Consequently, this decreases the number of sesame-free products available for […]
Following “lower than expected demand,” Nestlé is exploring strategic options for Palforzia [Peanut (Arachis hypogaea) Allergen Powder-dnfp], the first and only drug approved by the US FDA for the treatment of peanut allergy in children. Possible causes for the slow uptake of Palforzia include the COVID-19 pandemic, frequent doctor’s visits with additional time when escalating […]
Excipient enhanced growth (EEG) is progressing through toxicological studies and showing promise for treatment of asthma and lung cancer by delivering active molecules to target sites in the lungs. This article discusses development of two candidates, budesonide and gemcitabine, for local lung delivery using this formulation approach in combination with traditional spray drying for the […]
The United States Centers for Disease Control and Prevention (CDC) has published a report in the Annals of Allergy, Asthma and Immunology that offers recommendations and resources to assist allergists and immunologists in supporting patients as they become affected by climate change. In two articles, Healio interviewed two of the three report authors. They discuss […]
The SABINA study of SABA inhaler usage and risk of asthma exacerbations, funded by AstraZeneca, is the largest real-world observational data analysis of asthma inhaler therapy and has evaluated more than one million patients across 40 countries. In addition, at Queen Mary University of London, a study of more than 700,000 patient records evaluated SABA […]
Local treatment of lung cancer by the inhalation route is an emerging therapeutic area, particularly for early stages of the disease when the cancer is localized in the lung tissue. This article outlines manufacturing and formulation considerations for local treatment of lung cancer by dry powder inhaler and highlights three recent case studies. The article […]
AAFA has launched the Health Equity Advancement and Leadership (HEAL) program to address findings from its 2020 report about asthma disparities in America. Each year, the HEAL Innovation program will award funding and resources to four local, pilot, community-based asthma programs tailored to at-risk populations most impacted by asthma and will focus on needs of […]
HEI undertook the Global Burden of Disease from Major Air Pollution Sources (GBD-MAPS) project to determine which air pollution sources or fuels contribute most to outdoor PM2.5 concentrations and their associated health burden. The study provides the first comprehensive estimates at global, regional and national levels, which can help inform policy. A variety of results […]